assalamu alaikum i am looking for a book imam ghazali Mujrabat Imam ghazali Tibba rohani was Tibba Jismani. I have the book with me urdu but i am looking for an english version can anybody please tell me if this book has been translated into english and if i can get it anywhere. i will also like to know what the title of the translated versionis. walaikum salam
Beginning Guidance Ghazali Pdf
assalamu alaikum i am looking for a book imam ghazali Mujrabat Imam ghazali Tibba rohani was Tibba Jismani. I have the book with me urdu but i am looking for an english version can anybody please tell me if this book has been translated into english and if i can get it anywhere. i will also like to know what the title of the translated versionis. thanking you walaikum salam
Glory be to God, whose praise should precede every writing and every speech! May the blessings of God rest on Mohammed, his Prophet and his Apostle, on his family and companions, by whose guidance error is escaped!
The original arabic being right beside the english text allows one to immediately learn the prayers taught.the additional notes in the back also adds amazing insight and clarity to some of the points made by Imam Al-ghazali.
He was called The Proof of Islam and undoubtedly was worthy of the name, absolutely trustworthy (in respect of the Faith) How many an epitome (has he given) us setting forth the basic principles of religion: how much that was repetitive has he summarised, and epitomised what was lengthy. How many a simple explanation has he given us of what was hard to fathom, with brief elucidation and clear solution of knotty problems. He used moderation, being quiet but decisive in silencing an adversary, though his words were like a sharp sword-thrust in refuting a slanderer and protecting the high-road of guidance.[89]
Current guidelines generally aligned with PREDICT-FD on indicators of renal involvement, but most lacked specificity regarding cardiac indicators. The prognostic significance of neurological indicators such as white matter lesions (excluded by PREDICT-FD) was questioned in some guidelines and excluded from most. Some PREDICT-FD patient-reported signs (e.g., febrile crises) did not feature elsewhere. Key drivers of treatment initiation in PREDICT-FD were: (A) male sex, young age, and clinical findings (e.g., severe pain, organ involvement), (B) improving clinical outcomes and preventing disease progression, and (C) a family history of Fabry disease (especially if outcomes were severe). All guidelines aligned with (A) and several advocated therapy for asymptomatic male patients. There was scant evidence of (B) in current guidance: for example, no countries mandated ancillary symptomatic therapy, and no guidance advocated familial screening with (C) when diagnosis was confirmed. Barriers were misdiagnosis and a lack of biomarkers to inform timing of treatment. Review of patient histories generally found equal or greater support for treatment initiation with PREDICT-FD indicators than with other guidelines and revealed that the same case and guideline criteria often yielded different treatment recommendations.
Wider adoption of PREDICT-FD indicators at a national level could promote earlier treatment in Fabry disease. Clearer, more concise guidance is needed to harmonize treatment initiation in Fabry disease internationally.
As well as examining the clinical case for appropriate FD-specific treatment initiation [11], PREDICT-FD required participants to suggest and to vote on factors that may drive or impede treatment initiation. Here, we report the consensus reached on these drivers of and barriers to treatment initiation and examine whether current treatment guidelines might contribute to delays in starting treatment. Accordingly, we compared the PREDICT-FD consensus with FD guidelines from different countries and with guidance issued by the European Fabry Working Group (EFWG) in 2015 [1]. The timelines of when these guidelines were issued and when disease-specific therapies were approved internationally are shown in Fig. 1; unpublished guidelines are summarized in Additional file 1: Table S1. Finally, as a preliminary examination of whether guideline variations may delay FD-specific treatment initiation, we consider some examples of treatment recommendations by a subset of panel members applying different guidelines to the same anonymized medical histories of patients with FD.
Biomarkers indicative of cardiac damage identified in PREDICT-FD (Table 2) only featured in the guidelines from Canada [21]. Coverage of cardiac signs identifiable with cardiac magnetic resonance imaging (cMRI) varied considerably by country and was absent from the EFWG guidance [1]. Diastolic dysfunction, identified as an early sign of cardiac damage in PREDICT-FD [11], featured in guidance from Canada, Catalonia (Spain), Slovenia, and Switzerland; only Canadian guidance noted short PR interval on electrocardiogram as an early sign [21]. Guidance with respect to cardiac indicators was often generic; only Canadian guidelines provided very specific cardiac damage criteria [21].
White matter lesions featured in the EFWG guidance [1] and in Portuguese guidelines [22] in female and late-onset male patients; Canadian guidelines noted that the significance of such imaging abnormalities in FD was unclear (Table 3) [21]. Sudden hearing loss, excluded from the PREDICT-FD consensus, featured as possible justification for disease-specific therapy initiation in Canadian, French, Portuguese, and the EFWG guidance [1, 21,22,23]. Only Canadian guidance noted the potential significance of acute optic neuropathy [21]. Neuropathic pain is widely recognized as an important early sign in FD, although not necessarily as justification for disease-specific therapy initiation. Painful gastrointestinal neuropathy symptoms were noted only in PREDICT-FD [21], although gastrointestinal symptoms (pain, diarrhea) were represented in guidance from Canada, Portugal, Slovenia, and Switzerland.
Angiokeratoma featured only in guidelines as a supportive diagnostic sign, and only the Canadian and Slovenian guidance noted that biopsies other than renal or cardiac might be helpful aids to diagnosis or to ratify treatment initiation (Table 4) [21]. Only guidance from Portugal included abnormal hidrosis and exercise intolerance as supportive signs for treatment, and no other patient-reported signs (febrile crises, progression of signs/symptoms) featured in any guidelines.
For other patient groups, Portugal also advocates treatment of any pediatric patient (i.e., not only male patients with classical FD) who presents with certain signs (e.g., renal, cardiac, pain, abnormal hidrosis). Guidance from Catalonia (Spain), Portugal, Slovenia, Switzerland, and the UK associates additional criteria with initiation in women and men with late-onset disease (Additional file 1: Table S1) [26]. These include either evidence of renal, cardiac, or cerebrovascular (except in the UK) involvement for which causes other than FD have been excluded or evidence of specific FD-related complications, such as uncontrolled pain or gastrointestinal symptoms. In the Lazio region of Italy, guidance for female patients with classical disease and male patients with non-classical disease suggests therapy must be started at early clinical signs of organ involvement. Treatment of female patients with non-classical disease may be considered when early FD symptoms appear. In terms of the type of disease-specific therapy recommended, only Australia, Canada, Portugal, and the UK make recommendations about chaperone therapy as well as about ERT. In Canada, ERT rather than chaperone therapy is recommended in children with a confirmed diagnosis because the Canadian regulatory authority has restricted chaperone therapy use to adults (patients aged 16 years or older in the EU and the UK).
Comparison of the PREDICT-FD consensus criteria with wide-ranging international guidance for disease-specific therapy initiation in FD has identified inconsistencies that could be addressed to harmonize early treatment of patients with FD. Differences in indicators of cardiac involvement were particularly evident across the various guidelines reviewed. Delayed treatment initiation because of differences in access to disease-specific therapy may lead to worse outcomes in FD and could be largely avoided if guidelines were aligned. Guidelines revised or issued most recently were most likely to include specific early disease indicators identified in the PREDICT-FD initiative, and only the four most recently issued country guidelines included recommendations about chaperone therapy. Expanding guidance at country level to bring early disease indicators identified in PREDICT-FD to the attention of managing clinicians and updating guideline recommendations to provide, for example, the level of granularity on cardiac indicators seen in Canadian guidance would help to address regional treatment inequalities.
Guidance from Canada and Catalonia (Spain) covered the broadest set of cardiac indicators, and Canadian guidance provided specific criteria for most of these, notably those assessed by cMRI. All the reviewed national or regional guidelines included cardiac indicators, but most could have been defined more precisely or expanded to include other measures. Synthesis of detailed cardiac criteria for treatment initiation in FD may be possible from the various guidelines examined. Countries were mostly aligned on renal indicators, although attitudes to confirmatory renal biopsy varied. The value of such histological evidence is undisputed, but some countries exclude it whereas others recommend it in justifying disease-specific therapy. Most guidelines included metrics for patients with proteinuria, typically a manifestation of FD presenting later than some other renal indicators. However, retaining such indicators in guidance is useful to allow for delayed diagnosis. In terms of neurological signs, few countries considered white matter lesions to be supportive of treatment initiation, Canadian guidelines noting that their clinical significance in FD is unclear. 2ff7e9595c
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